{"id":5016,"date":"2018-02-02T16:43:19","date_gmt":"2018-02-02T07:43:19","guid":{"rendered":"https:\/\/www.ugpet.com\/blog\/?p=5016"},"modified":"2022-11-21T17:31:09","modified_gmt":"2022-11-21T08:31:09","slug":"%e3%83%8b%e3%83%b3%e3%83%8b%e3%82%af%e3%81%a8%e7%8a%ac","status":"publish","type":"post","link":"https:\/\/www.ugpet.com\/blog\/2018\/02\/02\/5016","title":{"rendered":"\u72ac\u3068\u30cb\u30f3\u30cb\u30af"},"content":{"rendered":"

\"\"\u30cb\u30f3\u30cb\u30af\uff08\u30ac\u30fc\u30ea\u30c3\u30af\uff09\u306b\u3064\u3044\u3066\u3001\u72ac\u306b\u3068\u3063\u3066\u6bd2\u3060\u304b\u3089\u4e00\u5207\u4e0a\u3052\u3066\u306f\u99c4\u76ee\u3068\u3044\u3046\u4e8b\u304c\u8a00\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u4e00\u65b9\u3067\u3001\u6709\u7528\u6027\u304c\u3042\u308b\u3068\u8a00\u308f\u308c\u69d8\u3005\u306a\u30d7\u30ec\u30df\u30a2\u30e0\u30c9\u30c3\u30b0\u30d5\u30fc\u30c9\u306b\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u679c\u305f\u3057\u3066\u3069\u3061\u3089\u304c\u672c\u5f53\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u30cb\u30f3\u30cb\u30af\u3068\u72ac\u306b\u95a2\u3059\u308b\u8ad6\u6587<\/h2>\n

\u30cb\u30f3\u30cb\u30af\u3068\u72ac\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u3092\u8abf\u67fb\u3057\u3066\u307f\u307e\u3057\u305f\u3002<\/p>\n

\u30cb\u30f3\u30cb\u30af\u306e\u6bd2\u6027\uff08\u6eb6\u8840\u6027\u8ca7\u8840\uff09<\/h3>\n
\n

PROCEDURE:4 dogs were given 1.25 ml of garlic extract\/kg of body weight (5 g of whole garlic\/kg) intragastrically once a day for 7 days. The remaining 4 contol dogs received water instead of garlic extract. Complete blood counts were performed, and methemoglobin and erythrocyte-reduced glutathione concentrations, percentage of erythrocytes with Heinz bodies, and percentage of eccentrocytes were determined before and for 30 days after administration of the first dose of garlic extract. Ultrastructural analysis of eccentrocytes was performed.<\/p>\n

\nRESULTS:Compared with initial values, erythrocyte count, Hct, and hemoglobin concentration decreased to a minimum value on days 9 to 11 in dogs given garlic extract. Heinz body formation, an increase in erythrocyte-reduced glutathione concentration, and eccentrocytes were also detected in these dogs. However, no dog developed hemolytic anemia.<\/p>\n

\n

\u5f15\u7528<\/span>Hematologic changes associated with the appearance of eccentrocytes after intragastric administration of garlic extract to dogs
Copyright: American Journal of Veterinary Research<\/p>\n<\/div>\n<\/blockquote>\n

\u3053\u306e\u8ad6\u6587\u3092\u8981\u7d04\u3059\u308b\u3068\u300c4\u982d\u306e\u72ac\u306b\u3001\u4f53\u91cd1kg\u3042\u305f\u308a1.25ml\u306e\u30cb\u30f3\u30cb\u30af\u62bd\u51fa\u72691\u65e51\u56de\u30927\u65e5\u9593\u4e0e\u3048\u305f\u5834\u5408\u306b\u3001\u5225\u306b\u30cb\u30f3\u30cb\u30af\u62bd\u51fa\u7269\u306e\u4ee3\u308f\u308a\u306b\u6c34\u3092\u4e0e\u3048\u3089\u308c\u305f4\u982d\u306e\u500b\u4f53\u3068\u6bd4\u3079\u3066\u30019\u65e5\u304b\u308911\u65e5\u76ee\u306b\u6eb6\u8840\u306e\u5146\u5019\u304c\u898b\u3089\u308c\u305f\u304c\u3001\u6eb6\u8840\u6027\u8ca7\u8840\u306f\u767a\u75c7\u3057\u306a\u304b\u3063\u305f\u300d\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

1.25ml\u306e\u30cb\u30f3\u30cb\u30af\u62bd\u51fa\u7269\u306f\u30015g(5,000mg)\u306e\u30cb\u30f3\u30cb\u30af\u306b\u76f8\u5f53\u3057\u307e\u3059\u3002\u4f53\u91cd5kg\u306e\u72ac\u3060\u3068\u7d66\u4e0e\u91cf\u306f25g\u306b\u3042\u305f\u308a\u307e\u3059\u306e\u3067\u3001\u76f8\u5f53\u91cf\u3092\u4e0e\u3048\u3089\u308c\u3066\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u304c\u3001\u305d\u308c\u3067\u3082\u6eb6\u8840\u6027\u8ca7\u8840\u306f\u767a\u75c5\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u305f\u3060\u3001\u30cb\u30f3\u30cb\u30af\u4e00\u7247\u304c\u5927\u51e18g\u3068\u8003\u3048\u308b\u3068\u3001\u843d\u3068\u3057\u305f\u308a\u3057\u3066\u8aa4\u98f2\u3057\u305f\u969b\u306e\u6442\u53d6\u91cf\u304c\u6709\u6bd2\u6027\u304c\u793a\u5506\u3055\u308c\u308b5g\/kg\u306b\u5230\u9054\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u3001\u72ac\u304c\u8fd1\u304f\u306b\u3044\u308b\u969b\u306e\u30cb\u30f3\u30cb\u30af\u306e\u53d6\u308a\u6271\u3044\u306b\u3064\u3044\u3066\u5341\u5206\u306a\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u30cb\u30f3\u30cb\u30af\u3068\u7cd6\u5c3f\u75c5<\/h3>\n
\n

The present study was carried out to investigate the hypoglycaemic effects of metformin and garlic (Allium sativum Linn) in alloxan-induced diabetic dogs. The anti-diabetic activity of garlic had never been investigated in experimental diabetic dogs. Twenty-one adult dogs were randomly allocated into three equal groups consisting of seven dogs. The first group was the diabetic control, the second was the metformin treated and the third was the garlic-treated group. This study aimed to test 14-day oral administration of garlic (100 mg\/kg) for its effects in alloxan-induced diabetic dogs in comparison with metformin (1,700 mg\/dog\/day) anti-diabetic activity. The mean decrease in blood glucose was 9.27 mg\/dl for metformin and 25.93 mg\/dl for garlic. The results showed that treatment with metformin non-significantly reduced blood glucose level (p\u2009>\u20090.05) and significantly increased serum insulin level in diabetic dogs (p\u2009<\u20090.05). In contrast to metformin, garlic resulted in a significant decrease in the level of blood glucose, with a concomitant significant increase in the serum insulin level in diabetic dogs (p\u2009<\u20090.05). Garlic had a mild but significant blood glucose-lowering effect and the long-term use of this agent may be advantageous, over chemical drugs, in alleviating some of the chronic diseases and complications caused by diabetes.<\/p>\n

\n

\u5f15\u7528<\/span>A comparison between metformin and garlic on alloxan-induced diabetic dogs<\/p>\n<\/div>\n<\/blockquote>\n

\u3053\u306e\u8ad6\u6587\u3092\u30cb\u30f3\u30cb\u30af\u306e\u8a18\u8f09\u3092\u4e2d\u5fc3\u306b\u8981\u7d04\u3059\u308b\u3068\u300c\u7cd6\u5c3f\u75c5\u306e\u72ac\u306b\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3092\u4e0e\u3048\u305f\u5834\u5408\u3068\u3001\u30cb\u30f3\u30cb\u30af\uff08100mg\/kg\uff09\u3092\u4e0e\u3048\u305f\u5834\u5408\u3068\u3092\u6bd4\u8f03\u3057\u305f\u3002\u53cc\u65b9\u3068\u3082\u8840\u7cd6\u5024\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u30cb\u30f3\u30cb\u30af\u306f\u8efd\u5ea6\u3067\u3042\u308b\u304c\u3001\u6709\u610f\u306b\u8840\u4e2d\u30b0\u30eb\u30b3\u30fc\u30b9\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u300d\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u4f53\u91cd1kg\u5f53\u305f\u308a100mg\u306e\u30cb\u30f3\u30cb\u30af\u3067\u8abf\u67fb\u3057\u3066\u3044\u307e\u3059\u3002\u30cb\u30f3\u30cb\u30af\u304c\u7cd6\u5c3f\u75c5\u306e\u72ac\u306b\u3068\u3063\u3066\u3001\u85ac\u3092\u4f7f\u3046\u3053\u3068\u306a\u304f\u8840\u7cd6\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30cb\u30f3\u30cb\u30af\u3068\u8102\u8cea\u7570\u5e38\u75c7\uff08\u9ad8\u8102\u8840\u75c7\uff09<\/h3>\n
\n

2. The hypolipidemic effects of Commiphora mukul (guggulu) and Alium sativum (Garlic powder) were screened in dog and Presbytis monkeys. 3. Progressive decrease in the mean values of cholesterol, triglycerides and phospholipids were conspicuous for forty eight hours following the administration of guggulu\/garlic powder. 4. 25 mg\/kg body weight garlic powder was more effective in lowering the serum cholesterol and triglycerides as compared with that of guggulu.<\/p>\n

\n

\u5f15\u7528<\/span>Hypolipidemic activity of guggal resin (Commiphora mukul) and garlic (Alium sativum linn.) in dogs (Canis familiaris) and monkeys (Presbytis entellus entellus Dufresne).<\/p>\n<\/div>\n<\/blockquote>\n

\u3053\u306e\u8ad6\u6587\u3092\u72ac\u306e\u8a18\u8f09\u3092\u4e2d\u5fc3\u306b\u8981\u7d04\u3059\u308b\u3068\u300c\u72ac\u306b\u30cb\u30f3\u30cb\u30af\u30d1\u30a6\u30c0\u30fc\uff0825mg\/kg\uff09\u3092\u4e0e\u3048\u305f\u5834\u5408\u3001\u30b0\u30c3\u30b0\u30eb\u3092\u4e0e\u3048\u305f\u5834\u5408\u3068\u6bd4\u8f03\u3057\u3066\u3001\u8840\u6e05\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u53ca\u3073\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u4f4e\u4e0b\u306b\u3064\u3044\u3066\u3001\u3088\u308a\u52b9\u679c\u7684\u3067\u3042\u3063\u305f\u300d\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u4f53\u91cd1kg\u5f53\u305f\u308a25mg\u306e\u30ac\u30fc\u30ea\u30c3\u30af\u30d1\u30a6\u30c0\u30fc\uff08\u4e7e\u71e5\u30cb\u30f3\u30cb\u30af\uff09\u3067\u8abf\u67fb\u3057\u3066\u3044\u307e\u3059\u3002\u8102\u8cea\u7570\u5e38\u75c7\uff08\u9ad8\u8102\u8840\u75c7\uff09\u306e\u72ac\u306b\u3068\u3063\u3066\u3001\u30cb\u30f3\u30cb\u30af\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u7dcf\u8ad6<\/h2>\n

\u30cb\u30f3\u30cb\u30af\u306e\u5371\u967a\u6027\u306b\u3064\u3044\u3066\u3001\u305d\u306e\u5143\u3068\u306a\u3063\u3066\u3044\u308b\u8ad6\u6587\u306f1\u756a\u76ee\u306b\u7d39\u4ecb\u3055\u305b\u3066\u9802\u3044\u305f\u3082\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u304c\u3001\u3053\u306e\u8ad6\u6587\u3067\u306f\u30da\u30c3\u30c8\u30d5\u30fc\u30c9\u306b\u542b\u307e\u308c\u308b\u3088\u3046\u306a\u91cf\u3067\u306e\u7d50\u679c\u3067\u306f\u306a\u304f\u3001\u3053\u306e\u7d50\u679c\u304b\u3089\u30da\u30c3\u30c8\u30d5\u30fc\u30c9\u306b\u542b\u307e\u308c\u3066\u3044\u308b\u30cb\u30f3\u30cb\u30af\u306e\u5371\u967a\u6027\u306b\u3064\u3044\u3066\u8ad6\u3058\u308b\u3079\u304d\u3067\u306f\u306a\u3044\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n

\u7cd6\u5c3f\u75c5\u3068\u8102\u8cea\u7570\u5e38\u75c7\u306e\u4f8b\u304b\u3089\u8003\u3048\u308b\u3068\u3001100mg\/kg\u7a0b\u5ea6\u306e\u30cb\u30f3\u30cb\u30af\u300125mg\/kg\u7a0b\u5ea6\u306e\u30ac\u30fc\u30ea\u30c3\u30af\u30d1\u30a6\u30c0\u30fc\u3067\u3042\u308c\u3070\u6709\u7528\u306a\u52b9\u679c\u304c\u898b\u8fbc\u3081\u305d\u3046\u3067\u3059\u3002\u30c9\u30c3\u30b0\u30d5\u30fc\u30c9\u3067\u3042\u308c\u3070\u3001\u5927\u51e1\u30cb\u30f3\u30cb\u30af\u30670.5%\u3001\u30ac\u30fc\u30ea\u30c3\u30af\u30d1\u30a6\u30c0\u30fc\u30670.125%\u7a0b\u5ea6\u306e\u542b\u6709\u91cf\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u6709\u6bd2\u6027\u306b\u3064\u3044\u3066\u8abf\u67fb\u3055\u308c\u305f1\u756a\u76ee\u306e\u8ad6\u6587\u306e\u969b\u306b\u4e0e\u3048\u3089\u308c\u305f\u91cf\u306e2%\uff08\u6709\u7528\u91cf\u306e\u7d0450\u500d\u306e\u91cf\uff09\u306b\u3042\u305f\u308a\u307e\u3059\u3002<\/p>\n

\u30da\u30c3\u30c8\u30d5\u30fc\u30c9\u306e\u8868\u8a18\u539f\u6750\u6599\u306e\u4e0b\u306e\u65b9\u306b\u8868\u793a\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u306b\u306f\u3001\u305d\u306e\u7a0b\u5ea6\u4ee5\u4e0b\u306e\u91cf\u304c\u6dfb\u52a0\u3055\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u3082\u3061\u308d\u3093\u5f0a\u793e\u304c\u88fd\u9020\u8ca9\u58f2\u3059\u308bZEN<\/a>\u30820.1%\u4ee5\u4e0b\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5fc5\u9808\u306e\u6804\u990a\u7d20\u3084\u5065\u5eb7\u306b\u826f\u3044\u3068\u3055\u308c\u308b\u98df\u54c1\u3067\u3082\u9069\u6b63\u91cf\u3092\u4e0a\u56de\u308c\u3070\u5bb3\u306b\u306a\u308b\u3053\u3068\u306f\u591a\u3005\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u72ac\u306b\u3068\u3063\u3066\u5fc5\u9808\u306e\u6804\u990a\u7d20\u3067\u3042\u308b\u30ca\u30c8\u30ea\u30a6\u30e0\u3082\u3001AAFCO\u306e\u57fa\u6e96\u306e50\u500d\u3092\u4e0e\u3048\u3089\u308c\u308c\u3070\u81f4\u6b7b\u91cf\u306b\u8fd1\u3044\u91cf\u306b\u306a\u308a\u307e\u3059\u3002\u30c9\u30c3\u30b0\u30d5\u30fc\u30c9\u306b\u3088\u304f\u4f7f\u7528\u3055\u308c\u308b\u30ab\u30e2\u30df\u30fc\u30eb\u3084\u30da\u30d1\u30fc\u30df\u30f3\u30c8\u3001\u30de\u30ea\u30fc\u30b4\u30fc\u30eb\u30c9\u3068\u3044\u3063\u305f\u30cf\u30fc\u30d6\u985e\u3068\u3055\u308c\u308b\u539f\u6599\u306b\u3064\u3044\u3066\u3082\u3001\u6709\u7528\u3068\u3055\u308c\u308b\u91cf\u306e50\u500d\u3092\u4e0e\u3048\u308c\u3070\u5614\u5410\u306a\u3069\u306e\u75c7\u72b6\u304c\u73fe\u308c\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n

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